R. E. McCullumsmith

Latest

• Assessing the effects of antipsychotic medications on schizophrenia functional analysis: a postmortem proteome study
• Schizophrenia: a disorder of broken brain bioenergetics
• KRSA: An R package and R Shiny web application for an end-to-end upstream kinase analysis of kinome array data
• Strategies to identify candidate repurposable drugs: COVID-19 treatment as a case example
• Cellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy
• Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection
• Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approach
• Using protein turnover to expand the applications of transcriptomics
• Similarities and dissimilarities between psychiatric cluster disorders
• Role of Astrocytes in Major Neuropsychiatric Disorders
• Emerging Kinase Therapeutic Targets in Pancreatic Ductal Adenocarcinoma and Pancreatic Cancer Desmoplasia
• Kinome Array Profiling of Patient-Derived Pancreatic Ductal Adenocarcinoma Identifies Differentially Active Protein Tyrosine Kinases
• A role for endothelial NMDA receptors in the pathophysiology of schizophrenia
• KEOPS complex expression in the frontal cortex in major depression and schizophrenia
• KEOPS complex expression in the frontal cortex in major depression and schizophrenia
• Consequences of NMDA receptor deficiency can be rescued in the adult brain
• Oxytocin's anti-inflammatory and proimmune functions in COVID-19: a transcriptomic signature-based approach
• Combining Neurobehavioral Analysis and In Vivo Photoaffinity Labeling to Understand Protein Targets of Methamphetamine in Casper Zebrafish
• Identification of new drug treatments to combat COVID19: A signature-based approach using iLINCS
• Signature-based approaches for informed drug repurposing: targeting CNS disorders
• Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator-activated receptor alpha
• Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter
• Adenosine Kinase Expression in the Frontal Cortex in Schizophrenia
• A bioinformatic inquiry of the EAAT2 interactome in postmortem and neuropsychiatric datasets
• Pioglitazone improves working memory performance when administered in chronic TBI
• Kinase network dysregulation in a human induced pluripotent stem cell model of DISC1 schizophrenia
• Measurement of lactate levels in postmortem brain, iPSCs, and animal models of schizophrenia
• Connectivity Analyses of Bioenergetic Changes in Schizophrenia: Identification of Novel Treatments
• Role of glutamatergic system and mesocorticolimbic circuits in alcohol dependence
• Neurotransmitter changes after traumatic brain injury: an update for new treatment strategies
• Chronic Dysregulation of Cortical and Subcortical Metabolism After Experimental Traumatic Brain Injury
• Sex differences in DEK expression in the anterior cingulate cortex and its association with dementia severity in schizophrenia
• Neuron-specific deficits of bioenergetic processes in the dorsolateral prefrontal cortex in schizophrenia
• Cell-subtype-specific changes in adenosine pathways in schizophrenia
• Defects in Bioenergetic Coupling in Schizophrenia
• The role of glutamate transporters in the pathophysiology of neuropsychiatric disorders
• Abnormalities of signal transduction networks in chronic schizophrenia
• Contrasting the Role of xCT and GLT-1 Upregulation in the Ability of Ceftriaxone to Attenuate the Cue-Induced Reinstatement of Cocaine Seeking and Normalize AMPA Receptor Subunit Expression
• Postsynaptic Density-95 Isoform Abnormalities in Schizophrenia
• Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression
• Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury
• Shaping plasticity: Alterations in glutamate transporter localization as a pathophysiological mechanism in severe mental illness
• Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia
• Systematic evaluation of data-independent acquisition for sensitive and reproducible proteomics-a prototype design for a single injection assay
• Tyrosine hydroxylase localization in the nucleus accumbens in schizophrenia
• Cortical PGC-1alpha-Dependent Transcripts Are Reduced in Postmortem Tissue From Patients With Schizophrenia
• Cell-specific abnormalities of glutamate transporters in schizophrenia: sick astrocytes and compensating relay neurons?
• Glutamate transporter splice variant expression in an enriched pyramidal cell population in schizophrenia
• Changes in cortical N-methyl-D-aspartate receptors and post-synaptic density protein 95 in schizophrenia, mood disorders and suicide
• Evidence for schizophrenia as a disorder of neuroplasticity
• Decreased chloride channel expression in the dorsolateral prefrontal cortex in schizophrenia
• Postmortem brain: an underutilized substrate for studying severe mental illness
• Regulation of extrasynaptic glutamate levels as a pathophysiological mechanism in disorders of motivation and addiction
• Increased G protein-coupled receptor kinase (GRK) expression in the anterior cingulate cortex in schizophrenia
• Localization of excitatory amino acid transporters EAAT1 and EAAT2 in human postmortem cortex: a light and electron microscopic study
• Altered serine/threonine kinase activity in schizophrenia
• Abnormal partitioning of hexokinase 1 suggests disruption of a glutamate transport protein complex in schizophrenia
• Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: an exploratory study using whole genome and novel kinome approaches
• Postmortem brain: an underutilized substrate for studying severe mental illness
• Update on the neurobiology of schizophrenia: a role for extracellular microdomains
• Abnormal N-linked glycosylation of cortical AMPA receptor subunits in schizophrenia
• Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy
• Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia
• AMPA receptor subunit expression in the endoplasmic reticulum in frontal cortex of elderly patients with schizophrenia
• Expression of equilibrative nucleoside transporter type 1 protein in elderly patients with schizophrenia
• Recent advances in targeting the ionotropic glutamate receptors in treating schizophrenia
• Regional differences in expression of beta-tubulin isoforms in schizophrenia
• Abnormal activity of the MAPK- and cAMP-associated signaling pathways in frontal cortical areas in postmortem brain in schizophrenia
• Endosomal trafficking of AMPA receptors in frontal cortex of elderly patients with schizophrenia
• Novel approaches to the study of postmortem brain in psychiatric illness: old limitations and new challenges
• Evidence for abnormal forward trafficking of AMPA receptors in frontal cortex of elderly patients with schizophrenia
• Vesicular glutamate transporter mRNA expression in the medial temporal lobe in major depressive disorder, bipolar disorder, and schizophrenia
• Abnormal glycosylation of EAAT1 and EAAT2 in prefrontal cortex of elderly patients with schizophrenia
• Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia
• Expression of four housekeeping proteins in elderly patients with schizophrenia
• Abnormal expression of glutamate transporter and transporter interacting molecules in prefrontal cortex in elderly patients with schizophrenia
• Cortical expression of glial fibrillary acidic protein and glutamine synthetase is decreased in schizophrenia
• Altered vesicular glutamate transporter expression in the anterior cingulate cortex in schizophrenia
• Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders
• Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia
• Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder
• Expression of excitatory amino acid transporter interacting protein transcripts in the thalamus in schizophrenia
• Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia
• Increased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophrenia
• Schizophrenia as a disorder of neuroplasticity
• Effects of 6-cyano-7-nitroquinoxaline-2,3-dione on nicotinic receptor subunit transcript expression in the rat brain
• Expression of ARHGEF11 mRNA in schizophrenic thalamus
• Expression of transcripts for the vesicular glutamate transporters in the human medial temporal lobe
• Molecular abnormalities of the glutamate synapse in the thalamus in schizophrenia
• CC-chemokine receptor 2 required for bleomycin-induced pulmonary fibrosis
• Differential effects of antipsychotics on haloperidol-induced vacuous chewing movements and subcortical gene expression in the rat
• Striatal excitatory amino acid transporter transcript expression in schizophrenia, bipolar disorder, and major depressive disorder