INDRA Results

Statements

databases psp cbn pc bel_lc signor biogrid tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi minerva creeds ubibrowser acsn |
| geneways tees gnbr isi trips rlimsp medscan eidos sparser reach reading
CDK5R1 affects AATK
| 3 1
CDK5R1 binds AATK.
| 3
CDK5R1 binds AATK. 1 / 1
| 1
sparser
"AATYK1A bound to the p35 activation subunit of Cdk5 in cultured cells and in mouse brains and colocalized with p35 on endosomes in COS-7 cells."
20422042
CDK5R1 binds AATK and PHY1. 1 / 1
| 1
sparser
"In this study, we investigated the interaction of AATYK1A with Cyclin-dependent kinase 5 (Cdk5)/p35, a proline-directed protein kinase that is predominantly expressed in neurons."
20422042
CDK5R1 binds CDK5R1 and AATK. 1 / 1
| 1
sparser
"The cyclin-dependent kinase 5 (Cdk5) activator p35 binds to LMTK1 at the C-terminal region of the kinase domain (Honma et al., xref )."
32714146
CDK5R1 phosphorylates AATK.
| 1
CDK5R1 phosphorylates AATK. 1 / 1
| 1
reach
"Both hAATYKs and KIAA0641 bound to and were phosphorylated by Cdk5 and p35."
14521924
AATK affects CDK5R1
1 | 3
AATK binds CDK5R1.
| 3
CDK5R1 binds AATK. 1 / 1
| 1
sparser
"AATYK1A bound to the p35 activation subunit of Cdk5 in cultured cells and in mouse brains and colocalized with p35 on endosomes in COS-7 cells."
20422042
CDK5R1 binds AATK and PHY1. 1 / 1
| 1
sparser
"In this study, we investigated the interaction of AATYK1A with Cyclin-dependent kinase 5 (Cdk5)/p35, a proline-directed protein kinase that is predominantly expressed in neurons."
20422042
CDK5R1 binds CDK5R1 and AATK. 1 / 1
| 1
sparser
"The cyclin-dependent kinase 5 (Cdk5) activator p35 binds to LMTK1 at the C-terminal region of the kinase domain (Honma et al., xref )."
32714146
AATK activates CDK5R1.
1 |
AATK activates CDK5R1. 1 / 1
1 |
signor
"Apoptosis-associated tyrosine kinase is a cdk5 activator p35 binding protein."
14521924
Bisphenol A affects AATK
3 |
Bisphenol A increases the amount of AATK.
1 |
Bisphenol A increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
30816183
Bisphenol A demethylates AATK.
1 |
Bisphenol A demethylates AATK. 1 / 1
1 |
ctd
No evidence text available
27312807
Bisphenol A decreases the amount of AATK.
1 |
Bisphenol A decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
24586524
AATK is modified
| 1 2
AATK is phosphorylated.
| 1
AATK is phosphorylated. 1 / 1
| 1
rlimsp
"Because our phospho–Ser-34 antibody was not sensitive enough to detect endogenous LMTK1 phosphorylation, we examined the cellular localization of phospho–Ser-34 by expressing exogenous LMTK1 in cortical neurons."
24672056
AATK is palmitoylated.
| 1
AATK is palmitoylated. 1 / 1
| 1
sparser
"Interestingly, both upstream and downstream proteins of LMTK1A are associated with endosomal membranes through different types of lipid modifications: Cdk5 binds to membranes via the N-terminal myristoylation of its activator protein p35, LMTK1 is palmitoylated at the N-terminal region of transmembrane sequences and Rab11 is modified by geranylgeranylation ( xref )."
32714146
AATK is methylated.
| 1
AATK is methylated. 1 / 1
| 1
sparser
"Aberrant methylation of AATK was also revealed in primary lung (40%) and breast (53%) cancers, but was found to be significantly less methylated in matching normal breast tissues (17%; p<0.01)."
25352953
AATK affects RAB11A
| 1 2
AATK inhibits RAB11A.
| 1
AATK inhibits RAB11A. 1 / 1
| 1
reach
"We previously showed that LMTK1 decreases the activity of Rab11A."
24672056
AATK binds RAB11A.
| 1
AATK binds RAB11A. 1 / 1
| 1
sparser
"LMTK1 associated with Rab11A-dependent endosomes in axons ( xref )."
24672056
AATK activates RAB11A.
| 1
AATK activates RAB11A. 1 / 1
| 1
reach
"Down-regulation of LMTK1 Ser/Thr kinase in cortical neurons increases Rab11A positive endosomal trafficking in a Cdk5 dependent manner, leading to dendrite growth and branching."
24672056
Troglitazone affects AATK
2 |
Troglitazone increases the amount of AATK.
1 |
Troglitazone increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
28973697
Troglitazone decreases the amount of AATK.
1 |
Troglitazone decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
12732648
Silicon dioxide affects AATK
2 |
Silicon dioxide increases the amount of AATK.
1 |
Silicon dioxide increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
29203145
Silicon dioxide decreases the amount of AATK.
1 |
Silicon dioxide decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
25895662
Retinoic acid affects AATK
| 1 1
Retinoic acid increases the amount of AATK.
| 1
Retinoic acid increases the amount of AATK. 1 / 1
| 1
reach
"Interestingly, RA induced a significant overexpression of AATYK, both in the presence or absence of tetracycline and resulted in its distribution throughout the cytoplasm, indicating that AATYK is pre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10837911
Retinoic acid activates AATK.
| 1
Retinoic acid activates AATK. 1 / 1
| 1
sparser
"To rule out any indirect effect of RA on the neurons and clearly dissociate the role of miR-338 from AATK activity, we created neural cell lines containing Tet-inducible recombinant AATK gene with or without intron-8, to permit the study of neuronal differentiation without activating the endogenous AATK gene by RA."
18684991
Benzo[a]pyrene affects AATK
2 |
Benzo[a]pyrene increases the amount of AATK.
1 |
Benzo[a]pyrene increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
18247414
Benzo[a]pyrene decreases the amount of AATK.
1 |
Benzo[a]pyrene decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
26238291
RAB11A affects AATK
| 1 1
RAB11A inhibits AATK.
| 1
RAB11A inhibits AATK. 1 / 1
| 1
reach
"Enhanced axonal outgrowth was diminished by the inactivation of Rab11A, placing LMTK1 upstream of Rab11A."
22573681
RAB11A binds AATK.
| 1
AATK binds RAB11A. 1 / 1
| 1
sparser
"LMTK1 associated with Rab11A-dependent endosomes in axons ( xref )."
24672056
Dietary Fats affects AATK
2 |
Dietary Fats increases the amount of AATK.
1 |
Dietary Fats increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
30120929
Dietary Fats decreases the amount of AATK.
1 |
Dietary Fats decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
22609946
Cyclin affects AATK
| 2
Cyclin phosphorylates AATK.
| 1
Cyclin phosphorylates AATK. 1 / 1
| 1
reach
"One could speculate that an active cyclin D/Cdk5 enzyme, with no known cellular substrate, may phosphorylate the Cdk5 binding protein, dbpA (CDelta)."
10100871
Cyclin binds AATK.
| 1
Cyclin binds AATK. 1 / 1
| 1
reach
"The cyclin dependent kinase 5 (Cdk5) activator p35 binds to LMTK1 at the C-terminal region of the kinase domain."
32714146
CDK5 affects AATK
| 2
CDK5 phosphorylates AATK.
| 1
CDK5 phosphorylates AATK. 1 / 1
| 1
reach
"To confirm these results, phosphorylation of hAATYKs or KIAA0641 by Cdk5 and p35 was directly examined in vitro."
14521924
CDK5 activates AATK.
| 1
CDK5 activates AATK. 1 / 1
| 1
reach
"C53 protein (also known as Cdk5rap3 and LZAP) was originally isolated as a Cdk5 activator p35 binding protein in a yeast two-hybrid screening using p35 as the bait protein, and subsequently identified as a caspase substrate (our unpublished results)."
19223857
CABIN1 affects AATK
| 1 1
CABIN1 phosphorylates AATK.
| 1
CABIN1 phosphorylates AATK. 1 / 1
| 1
sparser
"FK-506, a calcineurin inhibitor caused AATYK hyperphosphorylation under high KCl conditions."
19941067
CABIN1 dephosphorylates AATK.
| 1
CABIN1 leads to the dephosphorylation of AATK. 1 / 1
| 1
reach
"FK-506, a calcineurin inhibitor caused AATYK hyperphosphorylation under high KCl conditions."
19941067
AATK affects apoptotic process
| 2
AATK inhibits apoptotic process.
| 1
Mutated AATK inhibits apoptotic process. 1 / 1
| 1
reach
"In addition, mutations of AATYK on either the kinase domain or Ser 480, Ser 558, and Ser 566 residues suppressed the LK induced hyperphosphorylation and apoptosis, suggesting the involvement of self-kinase activity and these Ser residues in this process."
16100393
AATK activates apoptotic process.
| 1
reach
"Our data shows that AATK is up regulated by DHT treatment, Recent study showed that overexpression of AATK inhibits cell proliferation and promotes apoptosis but over expression of wildtype AATK was found to promote neurite out growth [XREF_BIBR]."
25781993
AATK affects STK39
1 1 |
AATK inhibits STK39.
1 |
AATK inhibits STK39. 1 / 1
1 |
signor
"Taken together, our data are consistent with aatyk1 indirectly inhibiting the spak/wnk4 activation of the cotransporter by scaffolding an inhibitory phosphatase in proximity to a stimulatory kinase."
17267545
AATK binds STK39.
1 |
STK39 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
14563843
AATK affects CDK5
| 1 1
AATK phosphorylates CDK5.
| 1
AATK phosphorylates CDK5. 1 / 1
| 1
sparser
"On the other hand, we did not detect phosphorylation of Cdk5 by hAATYKs or KIAA0641."
14521924
AATK activates CDK5.
| 1
AATK activates CDK5. 1 / 1
| 1
reach
"Apoptosis associated tyrosine kinase is a Cdk5 activator p35 binding protein."
14521924
AATK affects AATK
| 1 1
AATK decreases the amount of AATK.
| 1
AATK decreases the amount of AATK. 1 / 1
| 1
reach
"Furthermore, it was determined that transfection of 30 or 50nM miR-558 mimics and AATK specific siRNA markedly suppressed the mRNA and protein expression of AATK."
27485693
AATK activates AATK.
| 1
AATK activates AATK. 1 / 1
| 1
eidos
"Because LMTK1 is upstream of Rab11 , LMTK1 itself is also plausibly involved in those diseases ."
32714146
AATK
| 1
AATK phosphorylates itself. 1 / 1
| 1
sparser
"We had also tried to detect the kinase activity by autophosphorylation of hAATYKs or KIAA0641 but we could not."
14521924
Urethane affects AATK
1 |
Urethane decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
28818685
Titanium dioxide affects AATK
1 |
Titanium dioxide increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
23557971
Thioacetamide affects AATK
1 |
Thioacetamide decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
23411599
Tetraphene affects AATK
1 |
Tetraphene increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
26377693
Tetracycline affects AATK
| 1
Tetracycline increases the amount of AATK. 1 / 1
| 1
reach
"In five of the stable clones tested (S6, S10, S13, S14 and S16), removal of tetracycline induced significant AATYK expression."
10837911
Tetrachloromethane affects AATK
1 |
Tetrachloromethane decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
17484886
Tesaglitazar affects AATK
1 |
Tesaglitazar increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
21515302
Sunitinib affects AATK
1 |
Sunitinib decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
31533062
Sulforaphane affects AATK
1 |
Sulforaphane decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
31838189
Raloxifene hydrochloride increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
15576828
Quercetin affects AATK
| 1
Quercetin decreases the amount of AATK. 1 / 1
| 1
reach
"Quercetin decreased the expression of AATK, CDKN2A, EIF4E1B, and IGFBP3."
32410992
Protein kinase C-delta inhibitor affects AATK
| 1
Protein kinase C-delta inhibitor leads to the dephosphorylation of AATK. 1 / 1
| 1
reach
"However, LK induced hyperphosphorylation of AATYK at multiple sites was blocked by kainate, lithium, and protein kinase C-delta inhibitor."
16100393
Potassium(1+) affects AATK
| 1
Potassium(1+) phosphorylates AATK on serine. 1 / 1
| 1
reach
"In cultured cerebellar granule cells, low potassium concentrations result in apoptotic stimulation and a hyper-phosphorylation of AATYK at specific serine residues."
23073627
MiR-338-3p affects AATK
| 1
MiR-338-3p activates AATK. 1 / 1
| 1
reach
"In contrast, luciferase levels did not change significantly when the miR-338-5p mimic was co-transfected with this reporter plasmid, indicating that rat AATK mRNA is specifically targeted by miR-338-3p."
22363537
MiR-338 affects AATK
| 1
MiR-338 activates AATK. 1 / 1
| 1
reach
"To assess whether miR-338 can specifically target AATK mRNAs, B35 cells were co-transfected with the miR-338 expression vector and a luciferase reporter plasmid containing the rat AATK 3 ' UTR."
22363537
Lithium(1+) affects AATK
| 1
Lithium(1+) leads to the dephosphorylation of AATK. 1 / 1
| 1
reach
"However, LK induced hyperphosphorylation of AATYK at multiple sites was blocked by kainate, lithium, and protein kinase C-delta inhibitor."
16100393
Jinfukang affects AATK
1 |
Jinfukang increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
27392435
Hsa-miR-558 affects AATK
1 |
Hsa-miR-558 decreases the amount of AATK. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27485693
Hsa-miR-335-5p affects AATK
1 |
Hsa-miR-335-5p decreases the amount of AATK. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18185580
HAATYKs affects AATK
| 1
AATK binds hAATYKs. 1 / 1
| 1
reach
"Both hAATYKs and KIAA0641 bound to and were phosphorylated by Cdk5 and p35."
14521924
Ferric oxide affects AATK
1 |
Ferric oxide increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
25086211
Ethanol affects AATK
1 |
Ethanol increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
30319688
Doxorubicin affects AATK
1 |
Doxorubicin decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
29803840
Dimethyl sulfoxide affects AATK
| 1
Dimethyl sulfoxide increases the amount of AATK. 1 / 1
| 1
reach
"On the other hand, DMSO fails to induce apoptosis or AATYK expression in 32D cells transformed by the bcr-abl oncogene, suggesting that AATYK expression may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells."
9444961
Copper atom affects AATK
1 |
Copper atom increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
26033743
Clofibrate affects AATK
1 |
Clofibrate decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
17585979
Bis(2-ethylhexyl) phthalate decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
31163220
Benzo[b]fluoranthene increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
26377693
All-trans-retinoic acid decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
23724009
Aflatoxin B1 affects AATK
1 |
Aflatoxin B1 decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
21641981
Acetamide affects AATK
1 |
Acetamide increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
31881176
Abrine affects AATK
1 |
Abrine increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
31054353
TPTE2 affects AATK
1 |
TPTE2 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
TBC1D9B affects AATK
| 1
TBC1D9B activates AATK. 1 / 1
| 1
reach
"LMTK1 controls the GAP activity of TBC1D9B on Rab11A, and TBC1D9B mediates the LMTK1 activity on Rab11A."
31628178
TBC1D9B Rab11 GAP affects AATK
| 1
AATK binds TBC1D9B Rab11 GAP. 1 / 1
| 1
reach
"We recently showed that LMTK1 binds to TBC1D9B Rab11 GAP, as described below."
32714146
TAB1 affects AATK
1 |
TAB1 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
T-2 Toxin affects AATK
1 |
T-2 Toxin decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
31299295
Soot affects AATK
1 |
Soot decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
26551751
STYX affects AATK
1 |
STYX binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
STK39 affects AATK
1 |
STK39 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
14563843
SSR4 affects AATK
1 |
SSR4 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
SRC affects AATK
| 1
SRC phosphorylates AATK. 1 / 1
| 1
sparser
"Ser34 phosphorylation suppressed the tyrosine phosphorylation of AATYK1A by Src family kinases."
20422042
SP110 affects AATK
| 1
SP110 inhibits AATK. 1 / 1
| 1
reach
"Interestingly, our RNA-seq results revealed that Sp110 downregulates Aatk, Adrbk1, Atp1a3 and Dusp14 and upregulates Chek1 and Nod2 under both uninfected and infected conditions (XREF_FIG), and the qPCR results confirmed that Sp110 regulates these host dependent survival factors for intracellular Mtb (XREF_FIG), indicating that Sp110 controls Mtb survival and growth by regulating the expression of genes involved in bactericidal responses."
26912204
SLC25A22 affects AATK
1 |
SLC25A22 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
SLC25A13 affects AATK
1 |
SLC25A13 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
SLC25A12 affects AATK
1 |
SLC25A12 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
SLC25A11 affects AATK
1 |
SLC25A11 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
SLC25A1 affects AATK
1 |
SLC25A1 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
SBF1 affects AATK
1 |
SBF1 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
RabA11 affects AATK
| 1
RabA11 activates AATK. 1 / 1
| 1
reach
"Although we mentioned previously that axonal movements of RabA11 positive endosomes are enhanced in LMTK1 - / - neurons, detailed analysis had not yet been performed."
24672056
RCN1 affects AATK
1 |
AATK binds RCN1. 1 / 1
1 |
biogrid
No evidence text available
25852190
Plant Extracts affects AATK
1 |
Plant Extracts decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
23557933
Phosphatase affects AATK
| 1
Phosphatase binds AATK. 1 / 1
| 1
reach
"Yeast-2-hybrid and co-immunoprecipitation studies have demonstrated that SPAK and protein phosphatase 1 (PP1) both bind to AATYK."
23073627
PTPRR affects AATK
1 |
AATK binds PTPRR. 1 / 1
1 |
biogrid
No evidence text available
28065597
PTPN7 affects AATK
1 |
AATK binds PTPN7. 1 / 1
1 |
biogrid
No evidence text available
28065597
PTPN6 affects AATK
1 |
AATK binds PTPN6. 1 / 1
1 |
biogrid
No evidence text available
28065597
PTPN20 affects AATK
1 |
AATK binds PTPN20. 1 / 1
1 |
biogrid
No evidence text available
28065597
PTPN18 affects AATK
1 |
AATK binds PTPN18. 1 / 1
1 |
biogrid
No evidence text available
28065597
PTPN12 affects AATK
1 |
AATK binds PTPN12. 1 / 1
1 |
biogrid
No evidence text available
28065597
PTPN11 affects AATK
1 |
AATK binds PTPN11. 1 / 1
1 |
biogrid
No evidence text available
28065597
PTPDC1 affects AATK
1 |
AATK binds PTPDC1. 1 / 1
1 |
biogrid
No evidence text available
28065597
PTEN affects AATK
1 |
AATK binds PTEN. 1 / 1
1 |
biogrid
No evidence text available
28065597
PPP3CB affects AATK
1 |
AATK binds PPP3CB. 1 / 1
1 |
biogrid
No evidence text available
28065597
PPP3CA affects AATK
1 |
AATK binds PPP3CA. 1 / 1
1 |
biogrid
No evidence text available
28065597
PPP1CC affects AATK
1 |
AATK binds PPP1CC. 1 / 1
1 |
biogrid
No evidence text available
25852190
PPP1CB affects AATK
1 |
AATK binds PPP1CB. 1 / 1
1 |
biogrid
No evidence text available
28065597
PPP1CA affects AATK
1 |
AATK binds PPP1CA. 1 / 1
1 |
biogrid
No evidence text available
22321011
PPP1 affects AATK
| 1
PPP1 binds AATK. 1 / 1
| 1
sparser
"Furthermore, the physical interaction between PP1 and AATYK was required for inhibition of NKCC1 activity in Xenopus laevis oocytes."
17267545
PPM1M affects AATK
1 |
AATK binds PPM1M. 1 / 1
1 |
biogrid
No evidence text available
28065597
PPM1K affects AATK
1 |
AATK binds PPM1K. 1 / 1
1 |
biogrid
No evidence text available
28065597
PPM1F affects AATK
1 |
PPM1F binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
PPM1B affects AATK
1 |
AATK binds PPM1B. 1 / 1
1 |
biogrid
No evidence text available
28065597
PPM1A affects AATK
1 |
AATK binds PPM1A. 1 / 1
1 |
biogrid
No evidence text available
28065597
P4HA1 affects AATK
1 |
AATK binds P4HA1. 1 / 1
1 |
biogrid
No evidence text available
25852190
Msln affects AATK
| 1
AATK binds Msln. 1 / 1
| 1
sparser
"They furthermore indicate that Cdk5 can disrupt ERC formation via Ser34 phosphorylation of AATYK1A. Finally, our data suggest a mechanism by which AATYK1A signaling couples Cdk5 to Rab11A activity."
20553326
Menthol affects AATK
1 |
Menthol decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
26760959
MTMR9 affects AATK
1 |
MTMR9 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
MTMR8 affects AATK
1 |
MTMR8 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
MTMR6 affects AATK
1 |
AATK binds MTMR6. 1 / 1
1 |
biogrid
No evidence text available
28065597
MTMR10 affects AATK
1 |
AATK binds MTMR10. 1 / 1
1 |
biogrid
No evidence text available
28065597
LK affects AATK
| 1
LK phosphorylates AATK. 1 / 1
| 1
sparser
"However, LK-induced hyperphosphorylation of AATYK at multiple sites was blocked by kainate, lithium, and protein kinase C-delta inhibitor."
16100393
ILKAP affects AATK
1 |
ILKAP binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
HSPB1 affects AATK
1 |
AATK binds HSPB1. 1 / 1
1 |
biogrid
No evidence text available
25852190
HK affects AATK
| 1
HK phosphorylates AATK. 1 / 1
| 1
reach
"HK dependent hypophosphorylation of AATYK was controlled by L-type voltage dependent calcium channel mediated Ca2+ influx followed by Ca2 +-dependent protein phosphatase activity."
16100393
GSK-J4 affects AATK
1 |
GSK-J4 decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
29301935
GSK-3 inhibitors affects AATK
| 1
GSK-3 inhibitors activates AATK. 1 / 1
| 1
reach
"GSK-3 inhibitors blocked the K5 induced mobility shift of AATYK."
19941067
GAP affects AATK
| 1
GAP binds AATK. 1 / 1
| 1
sparser
"We recently showed that LMTK1 binds to TBC1D9B Rab11 GAP (Nishino et al., xref ), as described below."
32714146
FMR1 affects AATK
| 1
AATK binds FMR1. 1 / 1
| 1
sparser
"In vitro methylation of FMRP-bearing arginine substitutions inhibited sc1 binding but not AATYK binding."
20064924
EYA4 affects AATK
1 |
AATK binds EYA4. 1 / 1
1 |
biogrid
No evidence text available
28065597
EYA2 affects AATK
1 |
AATK binds EYA2. 1 / 1
1 |
biogrid
No evidence text available
28065597
Dietary Sucrose affects AATK
1 |
Dietary Sucrose increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
26033743
Delta(9)-tetrahydrocannabinol decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
12237329
DUSP9 affects AATK
1 |
AATK binds DUSP9. 1 / 1
1 |
biogrid
No evidence text available
28065597
DUSP6 affects AATK
1 |
AATK binds DUSP6. 1 / 1
1 |
biogrid
No evidence text available
28065597
DUSP5 affects AATK
1 |
AATK binds DUSP5. 1 / 1
1 |
biogrid
No evidence text available
28065597
DUSP14 affects AATK
1 |
DUSP14 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
DUSP1 affects AATK
1 |
AATK binds DUSP1. 1 / 1
1 |
biogrid
No evidence text available
28065597
DUPD1 affects AATK
1 |
AATK binds DUPD1. 1 / 1
1 |
biogrid
No evidence text available
28065597
DPM1 affects AATK
1 |
AATK binds DPM1. 1 / 1
1 |
biogrid
No evidence text available
25852190
DNAJA3 affects AATK
1 |
DNAJA3 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
DNAJA1 affects AATK
1 |
AATK binds DNAJA1. 1 / 1
1 |
biogrid
No evidence text available
25852190
Coal Ash affects AATK
1 |
Coal Ash decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
19000753
CDC25B affects AATK
1 |
CDC25B binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
CDC14A affects AATK
1 |
CDC14A binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
Benzo[k]fluoranthene increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
26377693
ATAD3A affects AATK
1 |
AATK binds ATAD3A. 1 / 1
1 |
biogrid
No evidence text available
25852190
AR-DBD affects AATK
| 1
AATK binds AR-DBD. 1 / 1
| 1
reach
"It was found that the interaction of two amino acid (G@K563, G@R568 and C@R568) with three nucleotides : GGC were mainly involved in stabilizing the interactions between AR-DBD and AATK ARE (XREF_FIG)."
25781993
AR affects AATK
| 1
AATK binds AR. 1 / 1
| 1
sparser
"It was found that the interaction of two amino acid (G@K563, G@R568 and C@R568) with three nucleotides: GGC were mainly involved in stabilizing the interactions between AR-DBD and AATK ARE ( xref )."
25781993
ACTC1 affects AATK
1 |
ACTC1 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects transport
| 1
AATK inhibits transport. 1 / 1
| 1
reach
"In addition, these results may suggest that Rab11A positive endosomes use mainly plus-end-distal microtubules for vesicle transport even in dendrites, because LMTK1 knockout did not increase the prevalence of retrograde transport of Rab11A positive endosomes in dendrites (XREF_TABLE)."
24672056
AATK affects transport endosomal vesicles neurons
| 1
AATK inhibits transport endosomal vesicles neurons. 1 / 1
| 1
eidos
"LMTK1 knockdown or knockout ( KO ) or the expression of a kinase-negative mutant stimulates the transport of endosomal vesicles in neurons , leading to the overgrowth of axons , dendrites , and spines ."
32714146
AATK affects supply membrane components
| 1
AATK inhibits supply membrane components. 1 / 1
| 1
eidos
"Therefore , a decrease in LMTK1 activity increases the supply of membrane components , leading to axon overgrowth , the stimulation of dendrite arborization , and an increase in the density of spines in cultured primary neurons ."
32714146
AATK affects primary neurons
| 1
AATK inhibits primary neurons. 1 / 1
| 1
eidos
"Therefore , a decrease in LMTK1 activity increases the supply of membrane components , leading to axon overgrowth , the stimulation of dendrite arborization , and an increase in the density of spines in cultured primary neurons ."
32714146
AATK affects overactivation Rab11A
| 1
AATK inhibits overactivation Rab11A. 1 / 1
| 1
eidos
"( B ) Downregulation of LMTK1 results in overactivation of Rab11A , leading to : ( 1 ) overgrowth of axons ; ( 2 ) higher dendrite arborization ; and ( 3 ) excessive dendritic spine formation ."
32714146
AATK affects mtb
| 1
AATK activates mtb. 1 / 1
| 1
reach
"They found that silencing of Aatk, Adrbk1, Atp1a3 and Dusp14 reduced Mtb survival to various extents, while silencing Chek1 resulted in an increase in the mycobacterial burden XREF_BIBR."
26912204
AATK affects hAATYKs
| 1
AATK binds hAATYKs. 1 / 1
| 1
reach
"Both hAATYKs and KIAA0641 bound to and were phosphorylated by Cdk5 and p35."
14521924
AATK affects endosomal transportation
| 1
AATK inhibits endosomal transportation. 1 / 1
| 1
eidos
"The downregulation of LMTK1 results in increased endosomal transportation , but its overexpression does not affect the basal endosomal transport ."
32714146
eidos
"Therefore , a decrease in LMTK1 activity increases the supply of membrane components , leading to axon overgrowth , the stimulation of dendrite arborization , and an increase in the density of spines in cultured primary neurons ."
32714146
reach
"AATK inhibits cell proliferation, migration and also promotes apoptosis in melanoma cells [XREF_BIBR]."
26154170
AATK affects cell migration
| 1
AATK activates cell migration. 1 / 1
| 1
reach
"We found that depletion of AATK mRNA in metastatic melanoma cell lines enhanced cell migration in cell line derived from metastatic melanomas."
24589855
reach
"For the first time, we provide evidence which shows that : 1) AATYK is an enzymatically active non receptor kinase localized in the cytoplasm close to the nuclear membrane, 2) On continued overexpress[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10837911
AATK affects branch
| 1
AATK inhibits branch. 1 / 1
| 1
reach
"LMTK1 knockdown increased the number of dendrites (XREF_FIG), the number of branch points (XREF_FIG), the total length of primary dendrites (XREF_FIG), and the number of crossings at both proximal and distal regions from the cell body (XREF_FIG)."
24672056
AATK affects axon overgrowth
| 1
AATK inhibits axon overgrowth. 1 / 1
| 1
eidos
"Therefore , a decrease in LMTK1 activity increases the supply of membrane components , leading to axon overgrowth , the stimulation of dendrite arborization , and an increase in the density of spines in cultured primary neurons ."
32714146
AATK affects TPTE2
1 |
TPTE2 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects TBC1D9B
| 1
AATK activates TBC1D9B. 1 / 1
| 1
eidos
"LMTK1 activates TBC1D9B , leading to the inactivation of Rab11A activity ."
32714146
AATK affects TBC1D9B Rab11 GAP
| 1
AATK binds TBC1D9B Rab11 GAP. 1 / 1
| 1
reach
"We recently showed that LMTK1 binds to TBC1D9B Rab11 GAP, as described below."
32714146
AATK affects TAB1
1 |
TAB1 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects Spine
| 1
AATK inhibits Spine. 1 / 1
| 1
eidos
"Therefore , a decrease in LMTK1 activity increases the supply of membrane components , leading to axon overgrowth , the stimulation of dendrite arborization , and an increase in the density of spines in cultured primary neurons ."
32714146
AATK affects STYX
1 |
STYX binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects SSR4
1 |
SSR4 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects SLC25A22
1 |
SLC25A22 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects SLC25A13
1 |
SLC25A13 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects SLC25A12
1 |
SLC25A12 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects SLC25A11
1 |
SLC25A11 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects SLC25A1
1 |
SLC25A1 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects SBF1
1 |
SBF1 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects RCN1
1 |
AATK binds RCN1. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects Phosphatase
| 1
Phosphatase binds AATK. 1 / 1
| 1
reach
"Yeast-2-hybrid and co-immunoprecipitation studies have demonstrated that SPAK and protein phosphatase 1 (PP1) both bind to AATYK."
23073627
AATK affects PTPRR
1 |
AATK binds PTPRR. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PTPN7
1 |
AATK binds PTPN7. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PTPN6
1 |
AATK binds PTPN6. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PTPN20
1 |
AATK binds PTPN20. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PTPN18
1 |
AATK binds PTPN18. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PTPN12
1 |
AATK binds PTPN12. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PTPN11
1 |
AATK binds PTPN11. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PTPDC1
1 |
AATK binds PTPDC1. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PTEN
1 |
AATK binds PTEN. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PPP3CB
1 |
AATK binds PPP3CB. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PPP3CA
1 |
AATK binds PPP3CA. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PPP1CC
1 |
AATK binds PPP1CC. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects PPP1CB
1 |
AATK binds PPP1CB. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PPP1CA
1 |
AATK binds PPP1CA. 1 / 1
1 |
biogrid
No evidence text available
22321011
AATK affects PPP1
| 1
PPP1 binds AATK. 1 / 1
| 1
sparser
"Furthermore, the physical interaction between PP1 and AATYK was required for inhibition of NKCC1 activity in Xenopus laevis oocytes."
17267545
AATK affects PPM1M
1 |
AATK binds PPM1M. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PPM1K
1 |
AATK binds PPM1K. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PPM1F
1 |
PPM1F binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PPM1B
1 |
AATK binds PPM1B. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PPM1A
1 |
AATK binds PPM1A. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects PHOX2B
| 1
AATK inhibits PHOX2B. 1 / 1
| 1
reach
"It was noted that the copy number gain of AATK and copy number loss of PHOX2B were the only CNVs detected in patients F1 and G2, respectively."
20064257
AATK affects P4HA1
1 |
AATK binds P4HA1. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects Msln
| 1
AATK binds Msln. 1 / 1
| 1
sparser
"They furthermore indicate that Cdk5 can disrupt ERC formation via Ser34 phosphorylation of AATYK1A. Finally, our data suggest a mechanism by which AATYK1A signaling couples Cdk5 to Rab11A activity."
20553326
AATK affects MTMR9
1 |
MTMR9 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects MTMR8
1 |
MTMR8 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects MTMR6
1 |
AATK binds MTMR6. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects MTMR10
1 |
AATK binds MTMR10. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects Leu-Lys
| 1
AATK activates Leu-Lys. 1 / 1
| 1
reach
"Overexpression of wild-type AATYK, but not its kinase deficient mutant, stimulates apoptosis in LK."
16100393
AATK affects ILKAP
1 |
ILKAP binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects HSPB1
1 |
AATK binds HSPB1. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects GAP
| 1
GAP binds AATK. 1 / 1
| 1
sparser
"We recently showed that LMTK1 binds to TBC1D9B Rab11 GAP (Nishino et al., xref ), as described below."
32714146
AATK affects FMR1
| 1
AATK binds FMR1. 1 / 1
| 1
sparser
"In vitro methylation of FMRP-bearing arginine substitutions inhibited sc1 binding but not AATYK binding."
20064924
AATK affects EYA4
1 |
AATK binds EYA4. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects EYA2
1 |
AATK binds EYA2. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects DUSP9
1 |
AATK binds DUSP9. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects DUSP6
1 |
AATK binds DUSP6. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects DUSP5
1 |
AATK binds DUSP5. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects DUSP14
1 |
DUSP14 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects DUSP1
1 |
AATK binds DUSP1. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects DUPD1
1 |
AATK binds DUPD1. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects DPM1
1 |
AATK binds DPM1. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects DNAJA3
1 |
DNAJA3 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects DNAJA1
1 |
AATK binds DNAJA1. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects Cyclin
| 1
Cyclin binds AATK. 1 / 1
| 1
reach
"The cyclin dependent kinase 5 (Cdk5) activator p35 binds to LMTK1 at the C-terminal region of the kinase domain."
32714146
AATK affects CDC25B
1 |
CDC25B binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects CDC14A
1 |
CDC14A binds AATK. 1 / 1
1 |
biogrid
No evidence text available
28065597
AATK affects ATAD3A
1 |
AATK binds ATAD3A. 1 / 1
1 |
biogrid
No evidence text available
25852190
AATK affects AR-DBD
| 1
AATK binds AR-DBD. 1 / 1
| 1
reach
"It was found that the interaction of two amino acid (G@K563, G@R568 and C@R568) with three nucleotides : GGC were mainly involved in stabilizing the interactions between AR-DBD and AATK ARE (XREF_FIG)."
25781993
AATK affects AR
| 1
AATK binds AR. 1 / 1
| 1
sparser
"It was found that the interaction of two amino acid (G@K563, G@R568 and C@R568) with three nucleotides: GGC were mainly involved in stabilizing the interactions between AR-DBD and AATK ARE ( xref )."
25781993
AATK affects ACTC1
1 |
ACTC1 binds AATK. 1 / 1
1 |
biogrid
No evidence text available
25852190
6-propyl-2-thiouracil decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
25825206
2-naphthylamine affects AATK
1 |
2-naphthylamine increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
18247414
2-hydroxypropanoic acid increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
30851411
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
32109520
17beta-estradiol affects AATK
1 |
17beta-estradiol decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
19484750
17alpha-ethynylestradiol decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
15576828
(S)-nicotine affects AATK
1 |
(S)-nicotine increases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
18247414
(+)-JQ1 compound affects AATK
1 |
(+)-JQ1 compound decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
26752646
4,4'-sulfonyldiphenol decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
30951980
3,3',4,4',5-pentachlorobiphenyl decreases the amount of AATK. 1 / 1
1 |
ctd
No evidence text available
32119087
3',5'-cyclic AMP affects AATK
| 1
3',5'-cyclic AMP decreases the amount of AATK. 1 / 1
| 1
reach
"The expression of AATK is downregulated by cAMP raising agents and by exposure to estradiol and GLP1 analogs (our unpublished observations)."
23287464
PHY1 affects CDK5R1
| 1
CDK5R1 binds AATK and PHY1. 1 / 1
| 1
sparser
"In this study, we investigated the interaction of AATYK1A with Cyclin-dependent kinase 5 (Cdk5)/p35, a proline-directed protein kinase that is predominantly expressed in neurons."
20422042